How do you administer fludarabine?

How do you administer fludarabine?

How do you administer fludarabine?

Usual Dose The recommended adult dose of FLUDARA (fludarabine) FOR INJECTION is 25 mg/m² administered intravenously over a period of approximately 30 minutes daily for five consecutive days. Each 5 day course of treatment should commence every 28 days.

Is fludarabine a chemotherapy?

Fludara is the trade name for fludarabine. In some cases, health care professionals may use the trade name fludara when referring to the generic drug name fludarabine. Drug type: Fludarabine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.

Is fludarabine soluble in water?

F-ara-A enters cells and accumulates as the 5′-triphosphate….Product Details.

Alternative Name: 2-Fluoroadenine-9-β-D-arabinofuranoside
Purity: ≥98% (HPLC)
Identity: Determined by IR.
Appearance: White to pale yellow crystalline powder.
Solubility: Sparingly soluble in water or organic solvents.

Does fludarabine cause mucositis?

Very common adverse events include myelosuppression (neutropenia, thrombocytopenia and anemia), fever and chills, fatigue, weakness, infection, pneumonia, cough, nausea, vomiting, and diarrhea. Other commonly reported events include malaise, mucositis and anorexia.

How is FCR administered?

You usually have FCR as a combination of tablets and a drip into your bloodstream (intravenously). Or you may have all the drugs as a drip into your bloodstream.

Do you lose hair with fludarabine?

This medicine may rarely cause a temporary loss of hair. After treatment with fludarabine has ended, normal hair growth should return.

What is the mechanism of action of cyclophosphamide?

MECHANISM OF ACTION: Cyclophosphamide is an alkylating agent of the nitrogen mustard type. 2 An activated form of cyclophosphamide, phosphoramide mustard, alkylates, or binds, to DNA. Its cytotoxic effect is mainly due to cross-linking of strands of DNA and RNA, and to inhibition of protein synthesis.

What is the fastest way to cure mucositis?

Actions that may help reduce the pain from mucositis: -In mild cases, ice pops, water ice, or ice chips may help numb the area, but most cases require more intervention for relief or pain. -Topical pain relievers include lidocaine, benzocaine, dyclonine hydrochloride (HCl), and Ulcerease® (0.6% Phenol).

What are the signs of mucositis?

What are the signs and symptoms of mucositis?

  • Red, shiny, or swollen mouth and gums.
  • Blood in the mouth.
  • Sores in the mouth, including on the gums or tongue.
  • Soreness or pain in the mouth or throat.
  • Trouble with swallowing or talking.
  • Feeling of dryness, mild burning, or pain when eating food.