How do you titrate warfarin?

How do you titrate warfarin?

A nice “rule of thumb” for dose adjustments near the target range (generally works for INRs from the high 1s to low 4s): If you want to change the INR by 0.5-1 unit, increase or decrease the weekly dose by a daily dose. Example: Your patient has been taking warfarin 5mg daily for more than 2 weeks and INR is 1.8.

When do you recheck INR?

The INR should be checked at least four times during the first week of therapy and then less frequently, depending on the stability of the INR. In general, a missed dose of warfarin is reflected in the INR within about 2 to 5 days after the dose is missed. (formerly DuPont Pharmaceutical) and Aventis corporations.

What is therapeutic INR for Coumadin?

An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung. In certain situations, such as having a mechanical heart valve, you might need a slightly higher INR.

When do you hold warfarin INR?

consider potential warfarin–drug interactions. wait at least 48 hours before testing INR after any change of dose, as earlier testing will not reflect the full response to the dose adjustment. if INR drifts below the target, avoid excessive increases in dose. provide ongoing patient education.

Is 10 mg of Coumadin too much?

If the patient’s CYP2C9 and VKORC1 genotypes are not known, the initial dose of COUMADIN is usually 2 to 5 mg once daily. Determine each patient’s dosing needs by close monitoring of the INR response and consideration of the indication being treated. Typical maintenance doses are 2 to 10 mg once daily.

How fast does INR Drop After stopping Coumadin?

In 5 patients studied in detail, the INR decreased exponentially and had a half-life that ranged from 0.52 to 1.2 days; the onset of maximal decrease began 24 to 36 hours after discontinuation of warfarin therapy.

Does Coumadin increase INR?

A high INR level can happen when you take warfarin (Coumadin). Warfarin helps prevent blood clots. To do this, it slows the amount of time it takes for your blood to clot. This raises your INR level.

Can you drink orange juice while taking warfarin?

Research has shown that certain fruits, particularly grapefruit and other citrus juices, can interfere with medication efficacy.