What are the components of endochondral bone development?

What are the components of endochondral bone development?

What are the components of endochondral bone development?

In endochondral ossification, bone develops by replacing hyaline cartilage. Cartilage does not become bone. Instead, cartilage serves as a template to be completely replaced by new bone. Endochondral ossification takes much longer than intramembranous ossification.

How does bone formation begin?

Bone development begins with the replacement of collagenous mesenchymal tissue by bone. Generally, bone is formed by endochondral or intramembranous ossification. Intramembranous ossification is essential in the bone such as skull, facial bones, and pelvis which MSCs directly differentiate to osteoblasts.

What are the 5 stages of bone growth?

30.2A: Stages of Bone Development

  • Initial Bone Formation.
  • Intramembranous Ossification.
  • Endochondral Ossification.
  • Remodeling.

Where does bone development first occur?

Endochondral ossification begins with points in the cartilage called “primary ossification centers.” They mostly appear during fetal development, though a few short bones begin their primary ossification after birth.

What is an example of an endochondral bone?

Endochondral bone: Any bone that develops in and replaces cartilage. The cartilage is partially or entirely destroyed by the process of calcification. The cartilage is then resorbed (reabsorbed), leaving bone in its place. Many bones are formed this way, particularly the long bones of the arms, legs, and ribs.

Which bones grow through endochondral ossification?

Endochondral ossification is the process by which growing cartilage is systematically replaced by bone to form the growing skeleton. This process occurs at three main sites: the physis, the epiphysis, and the cuboidal bones of the carpus and tarsus.

What is an example of Intramembranous bone?

Intramembranous ossification is the process of bone development from fibrous membranes. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles.

At what age are all bones normally ossified?


Time period Bones affected
18 to 23 years Bone of the lower limbs and os coxae become completely ossified
23 to 26 years Bone of the sternum, clavicles, and vertebrae become completely ossified
By 25 years Nearly all bones are completely ossified

How long does endochondral ossification take?

Endochondral formation occurs in the matrix template and external to the periosteum. The cartilaginous tissue forms a soft callus around 7 to 9 days posttrauma. Concurrently, intramembranous ossification commences from solid bone beneath the periosteum on each fracture end.

What is the last bone to complete its growth?

The clavicle (collar bone), pictured here, is the last bone to complete growth, at about age 25. Measuring the length of long bones can give an estimate of age for children, but this technique is useful only until bones have stopped growing.