What does oncocytic change mean?

What does oncocytic change mean?

Oncocytic change is defined as cellular enlargement characterised by an abundant eosinophilic granular cytoplasm as a result of the accumulation of altered mitochondria. This is a phenomenon of metaplasia that occurs in inflammatory disorders, such as thyroiditis, or other situations that result in cellular stress.

What does oncocytic mean?

Oncocytes are cells that have abundant eosinophilic cytoplasm due to the accumulation of mitochondria; they are also known as oxyphils.

What does oncocytic neoplasm mean?

Thyroid oncocytic tumors are neoplasms composed by a majority of cells with the morphologic features of oncocytes. Classification. Note. Oncocytic (Hürthle cell, oxyphilic cell, askanazi cell) adenoma: transcapsular and/or vascular invasion absent.

What is an oncocytic tumor?

Oncocytic carcinoma, also known as malignant oncocytoma, is a malignant carcinoma. It can occur in many organs, including the breast and the pancreas, but it occurs most frequently in the thyroid. 1. The occurrence of oncocytic carcinoma in the salivary glands has rarely been reported.

What is a follicular neoplasm?

Follicular neoplasm: A tumor that can be benign such as a thyroid adenoma, or malignant such as a follicular thyroid cancer.

Is Hurthle cell neoplasm malignant?

Like follicular tumors, there are both benign and malignant (cancerous) Hurthle cell tumors, and the pathologist evaluates the cells to look for differences that show an invasion of the capsule and the blood vessels. Benign Hurthle cell tumors are harmless and typically do not come back once they are removed.

What is an Oncocytic lesion?

Nodular oncocytic hyperplasia is a nonneoplastic epithelial lesion. It is most often seen in the parotid, and in the 5th, and 6th decades of life. Nodular oncocytic hyperplasia is a proliferation of oncocytic cells in multiple capsule-free solid – tubule-trabecular pattern.

What is low grade adenocarcinoma?

General Discussion. Polymorphous low-grade adenocarcinoma (PLGA) is a rare tumor of the salivary glands that is limited, to a great extent, to the minor salivary glands and commonly, but not exclusively, localized in the palate of the mouth.

Are oncocytomas malignant?

Most renal oncocytomas are benign (non-cancerous) and metastasis is very rare. Although many benign tumors do not require treatment unless they are causing unpleasant symptoms, it can be difficult to confidently differentiate a renal oncocytoma from renal cell carcinoma based on diagnostic imaging tests alone.

What is the treatment of follicular neoplasm?

The recommended treatment for follicular neoplasm is surgery, and up to 70% of these patients undergo surgery for benign disease. In this case, besides the increased costs, the patients are prone to increased risk of surgical morbidity.

Is follicular neoplasm curable?

Most thyroid cancers are very curable. In fact, the most common types of thyroid cancer (papillary and follicular thyroid cancer) are the most curable. In younger patients, less than 50 years of age, both papillary and follicular cancers have a more than 98% cure rate if treated appropriately.

Is there oncocytic change in papillary thyroid carcinoma?

Objective Although the presence of oncocytic change in less than 75% of a tumour is not considered to indicate oncocytic variants of papillary thyroid carcinoma (PTC), we frequently observe partial oncocytic change, especially in obese PTC patients. Thus, we sought to investigate the relationship between

How to diagnose follicular thyroid carcinoma ( FTC )?

Algorithm for the diagnosis of follicular thyroid carcinoma (FTC) and oncocytic (Hürthle cell) carcinoma. EBRT = external-beam radiation therapy; NA = fine-needle aspiration; RAI = radioiodine; TSH = thyroid-stimulating hormone; US = ultrasonography.

What kind of cancer is an oncocytic cyst?

Oncocytic changes can be seen in other thyroid cancer (Hürthle cell carcinoma, medullary carcinoma) and in other variants of papillary carcinoma (tall cell variant, Warthin-like variant) Either lobe or isthmus of thyroid gland, also in ectopic thyroid tissue, e.g., thyroglossal cyst or struma ovarii

What are the characteristic features of follicular thyroid carcinoma?

Table 5-1. Characteristic Features of Follicular and Oncocytic (Hürthle Cell) Carcinomas Based on studies identifying regions of differentiated thyroid carcinoma within anaplastic tumor, FTC or HCC may dedifferentiate into more aggressive poorly differentiated or anaplastic thyroid carcinoma.