What is direct acting vasodilator?

What is direct acting vasodilator?

What is direct acting vasodilator?

The most common are direct-acting nitrosovasodilators such as sodium nitroprusside and nitroglycerin. These drugs directly relax vascular smooth muscle to cause vasodilation. Hydralazine is another direct-acting smooth muscle vasodilator that is occasionally given to children to reduce blood pressure.

What are the most common vasodilators?

The most commonly used vasodilators are nitroprusside, nitroglycerin, and hydralazine. Nitroprusside and nitroglycerin, which have a fast onset and short duration of action, should be administered as continuous intravenous infusions.

What are some examples of vasodilators?

List of types and examples of generic and brand name vasodilators

  • benazepril (Lotensin)
  • captopril (Capoten)
  • enalapril (Vasotec, Epaned)
  • fosinopril (Monopril)
  • lisinopril (Prinivil, Zestril)
  • moexipril (Univasc)
  • perindopril (Aceon)
  • quinapril (Accupril)

Why is a direct vasodilator not a first line antihypertensive medication?

It is not first-line therapy for arterial hypertension. Its relatively short half-life, which necessitates frequent dosing, and its precipitation of reflex tachycardia make it undesirable for treating chronic hypertension.

Which drugs are direct vasodilators?


  • Direct-acting vasodilators (hydralazine, minoxidil, nitrates, nitroprusside)
  • Calcium channel blockers (verapamil, diltiazem, nifedipine, amlodipine)
  • An antagonist of the renin-angiotensin-aldosterone system (angiotensin receptor blockers, angiotensin-converting-enzyme inhibitors)

Is coffee a vasodilator?

Direct Effects. Caffeine, by acting on the VSMC, generates a minimal initial contraction and then a significant vasodilator effect.

What is the best natural vasodilator?

Leafy Greens. Leafy greens like spinach and collard greens are high in nitrates, which your body converts into nitric oxide, a potent vasodilator. Eating nitrate-rich foods may help improve circulation by dilating blood vessels, allowing your blood to flow more easily.

What does vasodilator stand for in medical category?

Vasodilators are medicines that dilate (widen) blood vessels, allowing blood to flow more easily through.

Why do vasodilators dilate the blood vessels?

As a result, blood flows more easily through your vessels. Your heart doesn’t have to pump as hard, reducing your blood pressure. Some drugs used to treat hypertension, such as calcium channel blockers — which prevent calcium from entering blood vessel walls — also dilate blood vessels.

How are vasodilators used at the Mayo Clinic?

By Mayo Clinic Staff. Vasodilators are medications that open (dilate) blood vessels. They affect the muscles in the walls of your arteries and veins, preventing the muscles from tightening and the walls from narrowing. As a result, blood flows more easily through your vessels.

Which is the most selective vasodilator in the world?

Most drugs that dilate arteries also dilate veins; however, hydralazine, a direct acting vasodilator, is highly selective for arterial resistance vessels.