What is exon array data?

What is exon array data?

The exon array consists of ∼1.4 million probesets and >5 million individual probes. Each probeset comprises four individual probes and usually corresponds to a single exon (longer exons may have more than one probeset designed to them).

What is Exon?

Exons are coding sections of an RNA transcript, or the DNA encoding it, that are translated into protein. Exons can be separated by intervening sections of DNA that do not code for proteins, known as introns.

What is microarray expression analysis?

A microarray is a laboratory tool used to detect the expression of thousands of genes at the same time. The DNA molecules attached to each slide act as probes to detect gene expression, which is also known as the transcriptome or the set of messenger RNA (mRNA) transcripts expressed by a group of genes.

Is microarray analysis expensive?

Microarrays are expensive. Depending on the platform, a single experiment can cost hundreds if not thousands of dollars, and there is currently no consensus about how many replicates need to be done, although the number, fortunately, appears to be low46, 47.

What is difference between exon and intron?

Introns are the transcribed part of the nucleotide sequence in an mRNA and bound to carry the non-coding part for the proteins. Exons are the transcribed part of the nucleotide sequence in mRNA that’s liable for the protein synthesis. The sequence of the introns frequently changes over time.

Are all exons coding?

The exons are the sequences that will remain in the mature mRNA. Thus, the exons contain both protein-coding (translated) and non-coding (untranslated) sequences. Also note that the transcription of all mRNAs begins and ends with an exon and introns are located between exons.

Are introns non coding?

In some genes, not all of the DNA sequence is used to make protein. Introns are noncoding sections of an RNA transcript, or the DNA encoding it, that are spliced out before the RNA molecule is translated into a protein. The sections of DNA (or RNA) that code for proteins are called exons.

Can exons be non-coding?

Non-coding exons can contain some regulatory elements that modulate the protein expression, such as enhancers, silencer, or small non-coding RNA.