What is iso-osmolar contrast?

What is iso-osmolar contrast?

Abstract. Iodinated contrast agents are usually classified based upon their osmolality—high, low, and isosmolar. Iodinated contrast agents are also nephrotoxic in some but not all patients resulting in loss of glomerular filtration rate.

What is low osmolar contrast?

Low osmolar contrast media (LOCM) have undergone further evolution with increased hydroxyl groups replacing carboxyl groups for additional solubility in water. The lower osmolality and increased solubility in water lowers LOCM toxicity.

Is omnipaque contrast high or low osmolar?

Is omnipaque an iso-osmolar?

Rockville (MD): Agency for Healthcare Research and Quality (US); 2007-….Table ALow-Osmolar and Iso-Osmolar Contrast Media.

What is the meaning of ISO osmotic?

Solutions containing the same concentration of particles and thus exerting equal osmotic pressures are called iso-osmotic. A 0.9% solution of NaCl (Normal Saline) is iso-osmotic with blood and tears. The term isotonic, meaning equal tone, is sometimes used interchangeably with the term iso-osmotic.

Which is low osmolality agents?

Classification of Contrast Materials Based on Osmolality Newer agents, although still more than three times the osmolality of blood, are of relatively low osmolality and are termed “low osmolar contrast media” (LOCM; up to 900 mOsm/kg H2O).

Is contrast dye nephrotoxic?

Older contrast dyes probably were nephrotoxic. However, modern contrast dyes (with lower osmolarity) don’t seem to cause renal failure. “Contrast nephropathy” is usually defined as a small increase in creatinine within the days following contrast administration (e.g. 0.3 mg/dL).

Is iohexol nephrotoxic?

Iohexol (Omnipaque 350) and iopamidol (Isovue 370) are nonionic monomers; ioxaglate (Hexabrix 320) is an ionic dimer. We compared the nephrotoxicity of these three media by a prospective double-blind evaluation in 500 patients who underwent peripheral angiography during a 6-month period.

Is there a difference between iso osmolar and locm?

Contrast-induced acute kidney injury (CI-AKI) is a major adverse effect caused by intravascular administration of iodinated contrast medium. Whether there is a difference in CI-AKI incidence between iso-osmolar (IOCM) and low-osmolar contrast media (LOCM) among diabetic patients is controversial.

What is the purpose of ISO-osmolality contrast medium?

Purpose: To determine the effects of iso-osmolality contrast medium compared with a low-osmolality agent on renal function (serum creatinine [SCr] and glomerular filtration rate [GFR]) in high-risk patients undergoing intravenous contrast material–enhanced CT.

Which is a better contrast media plasma or hyperosmolar?

Contrast media can be classified by their osmolarity. Hyperosmolar contrast agents have as much as five times the osmolarity of plasma (12). Newer contrast agents, termed low-osmolar and iso-osmolar contrast agents, have an osmolarity that is two or three times greater than that of plasma and equal to that of plasma, respectively (12).

What are the search keywords for iso osmolar?

Search keywords included “iso-osmolar”, “iodixanol”, “visipaque”, “IOCM” and “diabetes” as MeSH and free text terms. In addition, root variations of the mentioned keywords were used in order to improve search outcomes.