Which drug acts an estrogen receptor modulator?

Which drug acts an estrogen receptor modulator?

Tamoxifen, a nonsteroidal triphenylethylene antiestrogen and a widely used drug in the treatment of breast cancer. Selective estrogen receptor modulators (SERMs), also known as estrogen receptor agonist/antagonists (ERAAs), are a class of drugs that act on the estrogen receptor (ER).

What are the SERM drugs?

Two of the most common SERMs are tamoxifen (Nolvadex, Soltamox) and raloxifene (Evista). There are several others as well, including lasofoxifene, bazedoxifene, and clomiphene citrate. Keep reading to learn more about the types of SERMs and how they work to treat different conditions.

How does Evista work for osteoporosis?

Manufactured by the Eli Lilly Corporation, Evista increases the density of your bones. It does its work by mimicking the effects of estrogen, a hormone that, among other things, builds up bone tissue.

Why is raloxifene used in osteoporosis?

Raloxifene has been shown to prevent bone loss, and data in women with osteoporosis have demonstrated that this agent causes a 35% reduction in the risk of vertebral fractures. It has also been shown to reduce the prevalence of invasive breast cancer.

Does Arimidex build muscle?

Arimidex is a treatment for breast cancer that some bodybuilders take to reduce the side effects of anabolic steroids. The drug lowers estrogen levels in the body. Bodybuilders who take anabolic steroids to try to increase muscle mass and improve athletic performance can experience a range of symptoms.

Which drug is classified as an estrogen agonist antagonist?

The only estrogen agonists/antagonists that are currently US FDA approved for use in postmenopausal women are tamoxifen, toremifene and raloxifene. Tamoxifene and toremifene are FDA approved for the treatment of breast cancer and tamoxifen is also approved for the prevention of breast cancer.

Who should not take Evista?

Women who have or have had blood clots 99 in the legs, lungs, or eyes should not take EVISTA. 100 • Women who have had a heart attack or are at risk for a heart attack may have an 101 increased risk of dying from stroke when taking EVISTA.

Is Evista a good drug for osteoporosis?

Raloxifene is approved for the prevention and treatment of osteoporosis in postmenopausal women. It is in a class of drugs called estrogen agonists/antagonists that have been developed to provide the beneficial effects of estrogens without all of the potential disadvantages.

How long should you take Evista for osteoporosis?

In the STAR trial, women took Evista for 5 years. Depending on your unique situation, your doctor may recommend that you take Evista for a longer or shorter amount of time.

How long can you stay on raloxifene?

Background: Due to the chronic nature of osteoporosis and the risk of invasive breast cancer, raloxifene 60 mg/day (raloxifene) is intended to be used for long-term treatment (treatment >3 years).

What happens when you stop taking raloxifene?

Remaining still for a long time may increase the chance that you will develop a blood clot. Your doctor will probably tell you to stop taking raloxifene at least three days before a scheduled surgery and not to take the medication if you require an extended period of bed rest for any reason.