What is the use of prasugrel?

What is the use of prasugrel?

Prasugrel is used along with aspirin to prevent serious or life-threatening problems with the heart and blood vessels in people who have had a heart attack or severe chest pain and have been treated with angioplasty (procedure to open the blood vessels that supply blood to the heart).

What is the difference between prasugrel and ticagrelor?

In this investigator-initiated, randomized, multicenter trial, prasugrel was superior to ticagrelor with respect to the composite end point of death, myocardial infarction, or stroke at 1 year after randomization in patients with acute coronary syndromes who were scheduled to undergo invasive evaluation.

What is the difference between clopidogrel and prasugrel?

Prasugrel is a novel thienopyridine antiplatelet agent recently approved for the treatment of patients with ACS undergoing PCI. Prasugrel provides greater and more consistent platelet inhibition than clopidogrel due to earlier and more extensive formation of its active metabolite.

When do you use prasugrel over clopidogrel?

The 2016 American College of Cardiology/American Heart Association Dual Antiplatelet Therapy update recommends prasugrel over clopidogrel (class IIa recommendations) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) except for those who are at high risk for bleeding (such as …

Is prasugrel a blood thinner?

Effient (prasugrel) is a blood thinner that prevents heart attacks after a stent is placed in the heart.

What is side effect of prasugrel?

Tell your doctor right away if you have chest pain, a rash, itching, swelling of the face, lips, tongue, or throat, or trouble with swallowing or breathing while you are using the medicine. Do not stop taking this medicine without checking with your doctor first. To do so may increase your risk for clots.

When should you not use prasugrel?

Prasugrel should also be avoided with concomitant use of medications that increase bleeding risk (i.e. warfarin) and should be used with caution in patients with low body weight (less than 60 kg).

Can you drink alcohol on prasugrel?

You should be careful about drinking alcohol while taking Effient (prasugrel) or other blood thinners. Too much alcohol can raise your risk of stomach bleeding. If you are intoxicated, you can fall, hit your head, and have bleeding in the brain.

Can prasugrel cause black stools?

signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or.

Can prasugrel cause fatigue?

The risk of bleeding is higher in older adults. Common side effects may include: nosebleeds; or. easy bruising or bleeding….

What are the safety end points for prasugrel?

The primary efficacy end point was death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The key safety end point was major bleeding.

What’s the difference between clopidogrel and prasugrel?

Prasugrel — a novel thienopyridine — is a prodrug that, like clopidogrel, requires conversion to an active metabolite before binding to the platelet P2Y 12 receptor to confer antiplatelet activity.

What is the risk of major bleeding with prasugrel?

Major bleeding was observed in 2.4% of patients receiving prasugrel and in 1.8% of patients receiving clopidogrel (hazard ratio, 1.32; 95% CI, 1.03 to 1.68; P=0.03).

When did the manuscript for prasugrel come out?

The academic authors wrote all drafts of the manuscript and vouch for the veracity and completeness of its content. The database was locked on September 22, 2007; the analyses reported herein were completed on October 26, 2007.