What is the oxidative stress theory?

What is the oxidative stress theory?

The oxidative stress theory of aging postulates that age-associated reductions in physiologic functions are caused by a slow steady accumulation of oxidative damage to macromolecules, which increases with age and which is associated with life expectancy of organisms.

What is free radical theory?

The free radical theory proposes that ageing is the cumulative result of oxidative damage to the cells and tissues of the body that arises primarily as a result of aerobic metabolism.

What are the three stages of lipid oxidation?

The overall process of lipid peroxidation consists of three steps: initiation, propagation, and termination [31, 36, 37].

What is the mitochondrial DNA theory of aging?

Abstract. Mitochondrial theory of aging, a variant of free radical theory of aging, proposes that accumulation of damage to mitochondria and mitochondrial DNA (mtDNA) leads to aging of humans and animals.

What are the major biological theories of aging?

Modern biological theories of aging in humans fall into two main categories: programmed and damage or error theories. The programmed theories imply that aging follows a biological timetable, perhaps a continuation of the one that regulates childhood growth and development.

Who proposed free radical theory?

Denham Harman
The free radical theory of aging (26) was originally described by Denham Harman in the 1950s (11). It proposes that organisms age because they accumulate oxidative damage.

What is the difference between peroxidation and oxidation?

As nouns the difference between oxidation and peroxidation is that oxidation is the combination of a substance with oxygen while peroxidation is (chemistry) any oxidation reaction, especially of an oxide, that produces a peroxide.

How do you recognize lipid oxidation?

Lipid oxidation can be roughly estimated by measuring the UV absorption at 234 nm (conjugated dienes) and 268 nm (conjugated trienes) (Vieira and Regitano-d’Arce, 1999).

What is neuroendocrine theory?

The neuroendocrine theories view the functional decline in neurons and their associated hormones as central to aging. Given the major role the neuroendocrine system plays in physiology, this is an attractive theory of aging and neuroendocrine disease.

Is mitochondria responsible for aging?

Mitochondria have been increasingly recognized as the important players in the aging process. Mitochondrial DNA has an estimated 10-fold greater mutation rate than nuclear DNA and less repair capacity, and this plays an important role in aging and cancer.