What type of drug is Mekinist?

What type of drug is Mekinist?

Trametinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Is Mekinist FDA approved?

The U.S. Food and Drug Administration has approved Mekinist (trametinib) in combination with Tafinlar (dabrafenib) for the treatment of patients with unresectable melanoma or metastatic melanoma with the BRAF V600E or V600K mutations, as detected by an FDA-approved test.

How do you take Mekinist?

If taking MEKINIST BEFORE something to eat or drink, take it and then wait at least one (1) hour before having food or drink. If taking MEKINIST AFTER eating a meal or snack, wait at least two (2) hours before taking it. The usual dose of MEKINIST is one 2 mg tablet once a day.

Does Mekinist cause high blood pressure?

High blood pressure: Trametinib may increase your blood pressure. Your doctor will monitor your blood pressure while you are taking this medication.

What are the side effects of trametinib?

More common

• Burning, itching, and pain in hairy areas, pus at the root of the hair.
• canker sores.
• change in taste.
• dry eyes.
• dry skin.
• itching, pain, redness, swelling, tenderness, or warmth on the skin.
• loosening of the fingernails.
• loss of taste.

How long can you take Mekinist?

Recommended Dosage For The Adjuvant Treatment Of Melanoma The recommended dosage of MEKINIST is 2 mg orally taken once daily in combination with dabrafenib until disease recurrence or unacceptable toxicity for up to 1 year. Refer to the dabrafenib prescribing information for recommended dabrafenib dosing information.

Is Binimetinib FDA approved?

The FDA approved binimetinib based primarily on evidence from one clinical trial (NCT01909453) of 383 patients with BRAF V600 mutation-positive melanoma that was advanced or could not be removed by surgery. The trial was conducted at 162 sites in Europe, North America, and various countries around the world.

Is Cobimetinib FDA approved?

Mechanism: BRAF and MEK are proteins in a cell signaling pathway that help control cell growth and survival….Development Timeline for Cotellic.

How long can you take MEKINIST?

Can MEKINIST be cut?

Swallow Mekinist tablets whole. Do not crush or dissolve tablets. Do not change your dose or stop Mekinist unless your health care provider tells you to.

How much does Mekinist cost without insurance?

The cost for Mekinist oral tablet 0.5 mg is around $3,875 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. Mekinist is available as a brand name drug only, a generic version is not yet available.

Is trametinib a chemotherapy?

Trametinib is the generic name for the trade name chemotherapy drug Mekinist. In some cases, health care professionals may use the trade name Mekinist when referring to the generic name trametinib. Drug type: Trametinib is a targeted therapy.