What is GM-CSF antibody?

What is GM-CSF antibody?

Background: The role of anti-granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies as a diagnostic marker in idiopathic pulmonary alveolar proteinosis (iPAP) remains unclear. Methods: Anti-GM-CSF antibodies were detected in blood and bronchoalveolar lavage fluid (BAL) fluid in 13 patients with iPAP.

What does M-CSF stand for?

macrophage colony-stimulating factor
The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types.

What makes GM-CSF?

GM-CSF is produced by various cell types including macrophages, mast cells, T cells, fibroblasts and endothelial cells 8, 9, mostly in response to immune activation and cytokines that mediate inflammation.

Where is M-CSF produced?

bone marrow
M-CSF is produced in the bone marrow and by endothelial cells, fibroblasts, and mononuclear phagocytes. Its effects are felt locally; that is, M-CSF is not found in the blood circulation.

What are CSFs in immunology?

CSFs are a group of glycoproteins with molecular masses of 18 to 90 kDa, defined by their abilities to support proliferation and differentiation of hematopoietic cells of various lineages.

What’s the difference between GM-CSF and M CSF?

Important clues to their function come from their expression patterns. M-CSF exhibits a mostly homeostatic expression pattern, whereas GM-CSF is a product of cells activated during inflammatory or pathologic conditions.

How are GM-CSF and macrophage CSF dependent?

In the presence of both CSFs, some evidence of “competition” at the level of gene expression was observed. Care needs to be exercised when drawing definitive conclusions from a particular in vitro system about the roles of GM-CSF and M-CSF in macrophage lineage biology.

What is the role of M-CSF in tumor?

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate from Ly6C(hi) monocytes.

How does M-CSFR and GM-CSF receptor signaling differ?

M-CSFR signaling governs the phenotype of M2-like MHC-II lo TAM, and its blockade resulted in a preferential differentiation of monocytes to M1-like MHC-II hi TAM. Although GM-CSF receptor (GM-CSFR, CSF-2R, or CD116) signaling is not determining monocyte recruitment and differentiation, it fine tunes the molecular profile of MHC-II hi TAM]