Can multiple myeloma cause COPD?

Can multiple myeloma cause COPD?

Among 5186 patients with MM, approximately 15% had an asthma or COPD diagnosis (asthma/COPD) at baseline. The most commonly observed comorbidities among all MM patients and among those MM patients with asthma/COPD were cardiovascular disease, diabetes, and renal impairment.

How does multiple myeloma affect the lungs?

The intraparenchymal causes of respiratory failure from multiple myeloma include alveolar septal amyloidosis, plasma cell infiltration of lung parenchyma, accumulation of alveolar paraproteins, and metastatic calcification of the alveolar walls and blood vessels.

Can multiple myeloma metastasize to the lungs?

CONCLUSIONS: Extramedullary spread of multiple myeloma to the lung is uncommon and very rarely manifests in the form of pulmonary nodules. The presence of extramedullary disease at the time of diagnosis, occurring in over half of extramedullary cases of myeloma, has been associated with poor survival.

What is COPD pathogenesis?

The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung.

Does myeloma cause a cough?

Some of the symptoms you should watch for include fever, headache, severe aches and pains, shortness of breath, dizziness and persistent coughing. If these occur, it is likely it’s more than just a cold and you should see a doctor.

What parts of the body does COPD affect?

Chronic obstructive pulmonary disease (COPD) slowly damages the lungs and affects how you breathe. In COPD, the airways of the lungs (bronchial tubes) become inflamed and narrowed. They tend to collapse when you breathe out and can become clogged with mucus.

How is COPD detected?

Testing for COPD Spirometry is a simple test of how well your lungs work. For this test, you blow air into a mouthpiece and tubing attached to a small machine. The machine measures the amount of air you blow out and how fast you can blow it. Spirometry can detect COPD before symptoms develop.

What is the pathogenesis of multiple myeloma ( MM )?

Pathogenesis of myeloma Multiple myeloma (MM) is a neoplasm of post-germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and e …

How are B cells involved in multiple myeloma?

Multiple myeloma (MM) is a neoplasm of post-germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and end-organ sequelae.

How is bone disease related to multiple myeloma?

The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process. The interaction between myeloma cells and the bone microenvironment ultimately leads to the activation of osteoclasts and suppression of osteoblasts, resulting in bone loss.