What does BALB C stand for?

What does BALB C stand for?

Bagg Albino
BALB/c is an albino, immunodeficient inbred strain. BALB refers to Bagg Albino (inbred research mouse strain.

Are BALB c mice inbred?

Also Known As:C, BALBc, BALB, BALB/c BALB/cJ is a commonly used inbred. Key traits include a susceptibility to developing the demyelinating disease upon infection with Theiler’s murine encephalomyelitis virus.

Are BALB c mice genetically modified?

BALB/c is one of the most widely used and best characterized mouse strains in immunology. However, using the conventional microinjection technique it is extremely inefficient to produce transgenic BALB/c mice since the one-cell stage BALB/c embryos are highly vulnerable to pronuclear DNA microinjection.

Why are BALB c mice used?

BALB/c mice are useful for research into both cancer and immunology. Most substrains have a “long reproductive life-span”, are noted for displaying high levels of anxiety and for being relatively resistant to diet-induced atherosclerosis, making them a useful model for cardiovascular research.

What is the average lifespan of a lab mouse?

Mice in laboratories have lived much longer than wild mice with some studies recording normal mice living up to 4 years. Mutated mice bred in captivity have lived beyond four years with the longest life of a mouse being record at just short of 5 years.

What are BALB c mice used for?

In BALB/c mice, Th2 cells are more easily activated by immunization and this led the strain to be an excellent responder to immunization; thus, the BALB/c mice are used as a model for identifying genes that determine susceptibility to infectious and neoplastic diseases.

Are BALB C immunodeficient?

BALB/c Nude Mouse Details This mouse is inbred, and genetic monitoring results confirm it to be a BALB/c nude. The animal lacks a thymus, is unable to produce T-cells, and is therefore immunodeficient.

How old is a mouse in human years?

Mature adult mice range in age from 3 – 6 months; the life phase equivalent for humans ranges from 20 – 30 years. Figure.

What is the difference between C57BL 6 and BALB C?

BALB/c mice tend to produce a stronger humoral response than C57BL/6 mice. These strains have different gene sequences at the H2 site of the major histocompatibility (MHC)class I gene locus – BALB/c mice is H2d, while C57BL/6 is H2b. The difference in gene sequence of these two strains falls on the H2 locus.