What does CD20 positive mean?

What does CD20 positive mean?

CD20 positive T cell lymphoma is a rare condition that is characterized by the coexpression of CD20 and T cell markers, such as, CD3, CD5, or UCHL-11. Positivity for CD20 in any type of T cell lymphoma represents an aberrant immunophenotype, despite the presence of various indicators of T cell lymphoma.

What is CD20 in cancer?

A protein found on B cells (a type of white blood cell). It may be found in higher than normal amounts in patients with certain types of B-cell lymphomas and leukemias. Measuring the amount of CD20 on blood cells may help to diagnose cancer or plan cancer treatment. CD20 is a type of tumor marker.

What does CD in CD20 stand for?

CD is an abbreviation “for cluster of differentiation”. CD molecules are cell surface markers which are very useful for the identification and characterization of leukocytes and the different subpopulations of leukocytes. The number of CD markers has grown constantly and was expanded to other cell types.

Is Humira a anti-CD20?

Rituxan (rituximab) and Humira (adalimumab) are monoclonal antibodies used to treat arthritis.

What does CD45+ mean?

CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

What does rituximab do to CD20?

Rituximab targets CD20, a transmembrane protein present on virtually all B cells from the stage at which they become committed to B-cell development until it is downregulated when they differentiate into antibody-secreting plasma cells (Reff et al., 1994). Thus, CD20 is considered a pan-B-cell antigenic marker.

What kind of antibody is used to treat CD20?

It consists of an anti-CD20 murine IgG1 monoclonal antibody ibritumomab, linked to the radiolabeled isotope yttrium-90. 244 The monoclonal antibody portion of ibritumomab tiuxetan binds to CD20 specifically on the surface of malignant cells.

How is CD20 expression related to clinical outcome?

We determined the association between CD20 expression and clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL). The mean fluorescence intensity of CD20 and CD19 was determined by FCM, and the cytoplasmic expression of CD20 was determined by immunohistochemistry (IHC) on 272 diagnostic DLBCL samples.

Where is the CD20 gene located on a B cell?

B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. In humans CD20 is encoded by the MS4A1 gene. This gene encodes a member of the membrane-spanning 4A gene family.

How are CD20 markers related to lymphoma?

CD20 Marker and Relevance to Lymphoma 1 CD markers are molecules that are found on the surface of cells in our bodies. 2 CD Markers, B Cells, and T Cells. Lymphomas are cancers of the type of white blood cell known as… 3 CD20 is an antigen that is found on the surface of B cells but not T cells.