What is anti CD40?

What is anti CD40?

Upon intravenous administration, anti-CD40 monoclonal antibody SEA-CD40 binds to CD40 on a variety of immune cell types, triggering both cellular proliferation and activation of antigen-presenting cells (APCs), which activates B-cells and T-cells, and enhances the immune response against tumor cells.

What is CD40 a marker for?

In mice levels of CD40 are used as a marker to distinguish between inactivated and activated DCs, as its expression is up-regulated on DCs after encounter with microbial products (e.g. Toll-like receptor ligands) [40] and pathogens (e.g. viruses like HIV), as well as after uptake of apoptotic cells [41].

What does CD40 CD40L do?

CD40L/CD40 expression is known to be up-regulated in atheroma-associated cells. CD40L/CD40 interactions activate these cells by promoting the expression of molecules thought to be involved in atherosclerotic plaque formation, such as adhesion molecules, cytokines, matrix metalloproteinases, and tissue factor.

What is the main role of CD40 activation in B cells?

CD40-activated APCs up-regulate expression of B7 and MHC class II molecules (2, 13, 14, 15) and produce inflammatory cytokines, such as IL-12 (16, 17, 18). In turn, these molecules facilitate T cell activation and direct T cell differentiation (19). CD40 is also an important costimulatory molecule for B cells.

What is CFZ533?

CFZ533 (ISCALIMAB) is a fully human antibody that blocks CD40, a co-stimulatory protein involved in the activation of immune B-cells, which are crucial to the development of Sjogren’s syndrome. It is currently in Phase II of clinical trial for Sjogren’s Syndrome. CFZ533 (ISCALIMAB) is being developed by Novartis.

What cell expresses CD40?

In regard to expression pattern, CD40 was initially characterized on B cells and is also expressed on dendritic cells (DCs), monocytes, platelets, and macrophages as well as by non-hematopoietic cells such as myofibroblasts, fibroblasts, epithelial, and endothelial cells (7–9).

How is CD40 activated?

The B cell can present antigens to helper T cells. If an activated T cell recognizes the peptide presented by the B cell, the CD40L on the T cell binds to the B cell’s CD40 receptor, causing B cell activation.

What medications does Novartis make?

Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; production ceased 2020), terbinafine ( …

What will happen if a B cell does not undergo negative selection?

The mature B cell that moves into the periphery can be activated by antigen and become an antibody-secreting plasma cell or a memory B cell which will respond more quickly to a second exposure to antigen. B cells which fail to successfully complete B cell development undergo apoptosis (programmed cell death).

What are human CD40 immune cells?

CD40 is a Tumor Necrosis Factor Receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming. Thus, CD40 is a likely candidate to play roles in autoimmune diseases in which activated T and B cells cause pathology.

Are there any antibodies that detect CD40 ligand?

Antibodies that detect CD154 (CD40 Ligand) can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunocytochemistry, Functional View more CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells.

Which is the best antibody for CD154 antigen?

CD154 (CD40 Ligand) Antibodies. CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The View more. Synonyms. CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3;

How does CD40 ligand work in peripheral blood monocytes?

CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.