What is the name of the receptor for IGF-1 and what type of receptor is it?

What is the name of the receptor for IGF-1 and what type of receptor is it?

Type 1 insulin-like growth factor receptor (IGF1R) is a receptor tyrosine kinase that regulates cell growth and proliferation, and can be activated by IGF1, IGF2, and insulin. Here, we report the cryo-EM structure of full-length IGF1R–IGF1 complex in the active state.

What does IGF1R do?

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell.

Where are IGF-1 receptors located?

chromosome 15
The human IGF-1R is the product of a single-copy gene located on chromosome 15 and is ubiquitously expressed. The mature receptor is a tetramer consisting of 2 extracellular α-chains and 2 intracellular β-chains.

Can insulin bind to IGF-1 receptor?

Insulin and insulin-like growth factor-1 (IGF-1)2 are closely related hormones that control different aspects of growth and metabolism in many organisms. Insulin and IGF-1 fully activate their own receptor, but can also bind and activate the other receptor, although with reduced affinity.

What is a normal IGF-1 level?

Low IGF-1 is considered by most to be between 84–100 µ/l and numerous studies recommend that raising IGF-1 to high normal range reverses Chronic Medical Diseases (CMD), improves bone mineral density (BMD), and fibromyalgia.

Where is the insulin like growth factor 1 receptor located?

View/Edit Mouse. The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors.

What kind of receptors does IGF-1 bind to?

IGF-1 binds to at least two cell surface receptors: the IGF1 Receptor (IGFR), and the insulin receptor. The IGF-1 receptor seems to be the “physiologic” receptor – it binds IGF-1 at significantly higher affinity than it binds insulin.

What is the role of IGF-IR in prostate cancer?

Evidence suggests that IGF-IR signaling is required for survival and growth when prostate cancer cells progress to androgen independence. In addition, when immortalized prostate cancer cells mimicking advanced disease are treated with the IGF-1R ligand, IGF-1, the cells become more motile.

How is IGF-1R used to treat breast cancer?

In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor.