What is the pathophysiology of acute glomerulonephritis?

What is the pathophysiology of acute glomerulonephritis?

Acute glomerulonephritis (GN) comprises a specific set of renal diseases in which an immunologic mechanism triggers inflammation and proliferation of glomerular tissue that can result in damage to the basement membrane, mesangium, or capillary endothelium.

What is the pathogenesis of glomerulonephritis?

Recent evidence establishes that mesangial cell proliferation in glomerulonephritis is mediated by complement and platelets. Mesangial cell proliferation is accompanied by increased expression of PDGF and PDGF receptor proteins and the genes for these proteins resulting in an autocrine mechanism of cell proliferation.

What is glomerulonephritis Slideshare?

1. Glomerulonephritis. Glomerulonephritis • A variety of diseases can affect the glomerular capillaries • Glomerulonephritis is an inflammation of the glomerular capillaries membranes. • Caused by an immunologic reaction that result in proliferative and inflammatory change in glomerular structure.

What is the etiology of glomerulonephritis?

What causes acute glomerulonephritis? The acute disease may be caused by infections such as strep throat. It may also be caused by other illnesses, including lupus, Goodpasture’s syndrome, Wegener’s disease, and polyarteritis nodosa. Early diagnosis and prompt treatment are important to prevent kidney failure.

How is acute glomerulonephritis treated?

How is glomerulonephritis treated?

1. Changes to your diet so that you eat less protein, salt and potassium.
2. Corticosteroids such as prednisone.
3. Dialysis, which helps clean the blood, remove extra fluid and control blood pressure.
4. Diuretics (water pills) to reduce swelling.

What are the risk factors for glomerulonephritis?

What causes glomerulonephritis?

• High blood pressure.
• Diabetes.
• Cancer.
• Strep throat.
• Regularly taking more than the recommended dose of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, aspirin or naproxen.
• Bacterial infection of your heart.
• Viral infections, such as HIV, hepatitis B and hepatitis C.

What causes pathophysiology?

Pathophysiology ( a.k.a. physiopathology) – a convergence of pathology with physiology – is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury.

What are the risk factors of acute glomerulonephritis?

The risk factors for Acute Glomerulonephritis include: Having a condition which weakens the immune system and increases the risk of chronic infection, such as HIV or hepatitis viral infections. Bacterial infections such as strep throat.

What usually precedes acute glomerulonephritis?

Acute glomerulonephritis is primarily a disease of children older than 2 years of age, but it can occur at nearly any age. In most cases of acute glomerulonephritis, a group A beta-hemolytic streptococcal infection of the throat precedes the onset of glomerulonephritis by 2 to 3 weeks (Fig. 45-3).

What are the physical signs of acute glomerulonephritis (GN)?

The signs and symptoms of Acute Glomerulonephritis may include: Swollen face, especially observed in the early mornings Brown or pink urine; foaming urine Less frequent urination High blood pressure

How is acute glomerulonephritis (GN) treated?

For acute glomerulonephritis and acute kidney failure, dialysis can help remove excess fluid and control high blood pressure. The only long-term therapies for end-stage kidney disease are kidney dialysis and kidney transplant. When a transplant isn’t possible, often because of poor general health, dialysis is the only option.