When is cryoprecipitate preferred over fresh frozen plasma?

When is cryoprecipitate preferred over fresh frozen plasma?

Cryoprecipitate is preferred because it contains the same concentration of fibrinogen as FFP in less than one-twentieth of the volume. For example, the concentration of fibrinogen is approximately 1500 mg/dL in cryoprecipitate and 100-300 mg/dL in plasma.

Is cryoprecipitate better than FFP?

FFP contains coagulation factors at the same concentration present in plasma. Cryoprecipitate is a highly concentrated source of fibrinogen….

Why would you use cryoprecipitate over FFP?

Cryoprecipitate is used for hypofibrinogenemia, vonWillebrand disease, and in situations calling for a “fibrin glue.” Cryo IS NOT just a concentrate of FFP. In fact, a unit of cryo contains only 40-50% of the coag factors found in a unit of FFP, but those factors are more concentrated in the cryo (less volume).

Can fresh frozen plasma be transfused?

FFP must be thawed between 30 °C and 37 °C in a water bath under continuous agitation or with another system able to ensure a controlled temperature. The plasma must be transfused as soon as possible after thawing, but in any case within 24 hours, if stored at 4 ± 2 °C 4,5.

How many FFP does it take to correct INR?

The longer the pre-transfusion INR, the greater the correction achieved with a single unit of plasma. An INR of 12 can usually be corrected to an INR of 2 with only 2 bags of plasma. Whereas, as many as 4 bags of plasma may be necessary to correct an INR of 1.8 to less than 1.5.

When do you give platelets vs FFP?

Fresh frozen plasma infusion can be used for reversal of anticoagulant effects. Platelet transfusion is indicated to prevent hemorrhage in patients with thrombocytopenia or platelet function defects.

How long should fresh frozen plasma be transfused?

A unit of FFP is usually administered over 30 minutes. 170 – 200 micron filter is required (standard blood administration set). Once thawed, cryoprecipitate must not be re-frozen and should be used immediately. If delay is unavoidable, the component should be stored at ambient temperature and used within 4 hours.

Is FFP used to treat low platelets?

Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood. It is used to treat conditions in which there are low blood clotting factors (INR > 1.5) or low levels of other blood proteins. It may also be used as the replacement fluid in plasma exchange.

How fast can you infuse cryoprecipitate?

Cryoprecipitate should be infused through a standard blood filter at a rate of 4 to 10 mL/minute. At this rate, a pool of 10 bags can be infused in approximately 30 minutes.

How fast to infuse cryo?

The remainder of the blood can be infused to adults at a rate of 60-80 ml per hour. Complete the transfusion within two hours unless the patient can tolerate only gradual expansion of the intravascular volume. The infusion time should not exceed 4 hours.

What are the components of fresh frozen plasma?

Greater care should be taken in people with protein S deficiency, IgA deficiency , or heart failure. Fresh frozen plasma is made up of a complex mixture of water, proteins, carbohydrates, fats, and vitamins.

Is cryoprecipitate FFP?

Cryoprecipitate, or cryo for short, is a fresh frozen plasma (FFP)-derived concentrate including fibrinogen , factors VIII and XIII, von Willebrand factor , and fibronectin.