Are aminoglycosides linear kinetics?

Are aminoglycosides linear kinetics?

Aminoglycosides exhibit linear kinetics…just like vancomycin! Recall that this means a change in dose will produce a proportional change in serum concentration. It also means that a constant proportion of drug is eliminated over time.

Are aminoglycosides active against gram-positive?

Aminoglycosides are potent bactericidal antibiotics that act by creating fissures in the outer membrane of the bacterial cell. They are particularly active against aerobic, gram-negative bacteria and act synergistically against certain gram-positive organisms.

What are the pharmacokinetics of aminoglycosides?

For practical purposes, aminoglycosides are neither protein bound nor biotransformed. The major route of elimination is glomerular filtration, and aminoglycosides undergo some tubular reabsorption. Relevant pharmacokinetic parameters from significant studies have been tabulated.

What is the most toxic reaction to chloramphenicol?

The most serious adverse effect of chloramphenicol is bone marrow depression. Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia) are known to occur after the administration of chloramphenicol.

What is the half life for aminoglycoside antibiotics in the blood quizlet?

These drugs are not metabolized. In patients with normal renal function, half-lives of the aminoglycosides range from 2-3 hrs.

What is an example of an aminoglycoside?

The aminoglycosides include gentamicin, amikacin, tobramycin, neomycin, and streptomycin.

Which drugs are aminoglycosides?

The aminoglycoside class of antibiotics consists of many different agents. In the United States, gentamicin, tobramycin, amikacin, plazomicin, streptomycin, neomycin, and paromomycin are approved by the US Food and Drug Administration (FDA) and are available for clinical use.