How does multiple myeloma affect diabetes?

How does multiple myeloma affect diabetes?

Approximately, 20% of patients with newly diagnosed multiple myeloma can present with renal insufficiency, and up to 40% of patients with type 2 diabetes mellitus can be affected with diabetic nephropathy [42]. Nephropathy associated with multiple myeloma is usually due to abnormal light chains deposition.

What is pathogenesis of multiple myeloma?

The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process. The interaction between myeloma cells and the bone microenvironment ultimately leads to the activation of osteoclasts and suppression of osteoblasts, resulting in bone loss.

Which pathological state occurs in case of multiple myeloma?

Multiple myeloma (MM) is a clonal plasma cell proliferative disorder characterized by the abnormal increase of monoclonal paraprotein leading to evidence of specific end-organ damage. MM is part of the spectrum of monoclonal gammopathy.

Who is most likely to get multiple myeloma?

Your risk of multiple myeloma increases as you age, with most people diagnosed in their mid-60s. Male sex. Men are more likely to develop the disease than are women. Black race.

What is the Pathophysiology of Diabetes Type 2?

The pathophysiology of type 2 diabetes mellitus is characterized by peripheral insulin resistance, impaired regulation of hepatic glucose production, and declining β-cell function, eventually leading toβ -cell failure.

Where does multiple myeloma start?

Doctors know that myeloma begins with one abnormal plasma cell in your bone marrow — the soft, blood-producing tissue that fills in the center of most of your bones. The abnormal cell multiplies rapidly.

What is the pathogenesis of multiple myeloma ( MM )?

Pathogenesis of myeloma Multiple myeloma (MM) is a neoplasm of post-germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and e …

Is there a link between multiple myeloma and diabetes?

In a phase 3 Apex trial in patients with relapsed multiple myeloma by Richardson et al., 18% patients had either a baseline glycosylated hemoglobin higher than normal upper level or a history of diabetes [5]. In other reports, the prevalence was between 11% and 22% [6, 7].

How are B cells involved in multiple myeloma?

Multiple myeloma (MM) is a neoplasm of post-germinal center, terminally differentiated B cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within the bone marrow (BM) and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and end-organ sequelae.

How does prednisone work to treat multiple myeloma?

Glucose Control in Multiple Myeloma Dexamethasone- and prednisone-based regimens are part of the conventional and new methods to treat newly diagnosed or recurrent/multiple myeloma, These medications raise blood glucose through increased insulin resistance, gluconeogenesis, glycogenolysis, and decreased insulin production and secretion [20].