What are susceptible to tetracyclines?

What are susceptible to tetracyclines?

Resistance to tetracyclines is usually attributed to one or more of the following: the acquisition of mobile genetic elements carrying tetracycline-specific resistance genes, mutations within the ribosomal binding site, and/or chromosomal mutations leading to increased expression of intrinsic resistance mechanisms.

What specific bacterial structures does tetracycline work on?

Tetracycline works by binding specifically to the 30S ribosome of the bacteria, preventing attachment of the aminoacyl tRNA to the RNA-ribosome complex. It simultaneously inhibits other steps of the protein biosynthesis.

What antibiotics are in the tetracycline family?

Although tetracyclines all work in the same way, there are differences between the four tetracyclines (demeclocycline, doxycycline, minocycline, and tetracycline) that are available in the U.S….What are the differences between tetracyclines?

Is E coli susceptible to tetracycline?

coli infections in humans, but resistance to tetracycline is still common in E. coli (4, 7), which suggests that resistance has been selected by a bystander effect on commensal E. coli, during treatment of other pathogens in humans or animals.

What does tetracycline do to bacteria?

Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline.

Why does tetracycline only affect bacteria?

Tetracyclines act by interfering with the ability of a bacterium to produce certain vital proteins; thus, they are inhibitors of growth (bacteriostatic) rather than killers of the infectious agent (bacteriocidal) and are effective only against multiplying microorganisms.

Does tetracycline cause liver damage?

The liver injury was designated as cholestatic, hepatocellular, and mixed, with similar frequencies. Conclusions: Low-dose, oral tetracyclines constitute a likely cause of acute liver damage with a variable biochemical profile. Such reactions are probably very rare.