What does serum sickness look like?

What does serum sickness look like?

The key features of serum sickness and serum sickness-like reactions (SSLRs) are rash, fever and polyarthritis. Signs and symptoms of true serum sickness occur one to two weeks after first exposure, while SSLRs usually develop after 5 to 10 days.

What drugs cause serum sickness-like reaction?

Causes. Agents that have been implicated in serum sickness–like reactions include cefaclor, amoxicillin, sulfonamides, tetracyclines, ciprofloxacin, nonsteroidal anti-inflammatory drugs, barbiturates, carbamazepine, propranolol, thiouracil, and allopurinol.

How long does it take for serum sickness to go away?

The symptoms typically occur one to two weeks after exposure to an offending agent and resolve within several weeks of discontinuation.

Is serum sickness fatal?

Serum sickness is typically self-limited and resolves within days. The prognosis of serum sickness in patients without internal organ involvement is good. Although occasional reports show mortality resulting from progressive glomerulonephritis or severe neurological complications.

Who gets serum sickness?

Who gets serum sickness-like reaction? Serum sickness-like reaction is most commonly seen in young children (< 6 years of age) following the use of cefaclor (an antibiotic).

Can serum sickness last for months?

Treatment of serum sickness-like reaction Affected children usually recover within a few days of ceasing the offending medication, without any consequences. There have been reports of prolonged rash and/or joint symptoms lasting for several months but these have eventually resolved completely.

How long does serum sickness from a bee sting last?

The majority of the time, the symptoms of bee sting serum sickness will improve on their own within 48 hours. As the chemical from the bee toxin is filtered out of your body, the sickness will begin to go away.

Who is at risk for serum sickness?

The incidence of serum sickness due to thymoglobulin in renal transplant recipients has been estimated to be between 7 and 27%. There is an increased risk of developing serum sickness to thymoglobulin if there has been significant past exposure to rabbits or horses.

How long does Arthus reaction last?

Those clinical manifestations usually can persist for one week, or even persisting for few months, without scar left after healing. However, the mild necrosis at the injection site, sclerosis in the deep tissue, and even severe necrosis and ulceration in local tissues, skin, and muscles can be found in severe cases.