What is MIB index?

What is MIB index?

The MIB-1 labeling index was defined as the percentage of immunoreactive tumor cells in the evaluated area. Vascular components and hematogenous cells were excluded. The evaluated areas also excluded necrotic, degenerated, and poorly preserved areas.

What does high proliferation index mean?

In general, a high proliferation index suggests malignancy and high-grade tumors. Among solid tumors, the clinical significance of the proliferation index on breast cancer has been extensively studied.

What is Labelling index?

The Ki67 labelling index (LI – proportion of staining cells) is widely used to reflect proliferation in breast carcinomas. Several cut-off values have been suggested to distinguish between tumours with low and high proliferative activity.

What is normal cell proliferation?

The process by which cells grow and divide to replenish lost cells is termed cell proliferation. This is a highly regulated activity in normal, healthy tissue.

What does low proliferation rate mean?

Proliferation rate provides more information about how fast the cancer cells are dividing. Doctors commonly use a measure called “Ki-67” to describe the proliferation rate. A low Ki-67 percentage means slowly dividing cells, and a high Ki-67 (over 20%) means quickly dividing cells.

Does a high KI-67 score mean that I have a malignant Tumour?

Understanding Your Ki-67 Results A “high” score means that the breast tumor is more likely to be aggressive and spread quickly. Even so, not all doctors order the Ki-67 test, so don’t be alarmed if it’s not on your pathology report.

What is considered a high KI-67 score lymphoma?

The mean Ki-67 PI ranged from 26.6% in indolent lymphomas to 97.6% in very aggressive lymphomas (P < 0.001). The index was <45% in 82.8% of indolent lymphomas and >45% in 85% of aggressive lymphomas (AUC = 0.877, P < 0.001).