What is the mevalonate pathway responsible for?

What is the mevalonate pathway responsible for?

The mevalonate pathway, fundamental for cholesterol synthesis, is one of the most important metabolic networks in the cell; it provides essential cell constituents, such as cholesterol, and some of its branches produce key metabolites, such as geranylgeranyl pyrophosphate and farnesyl pyrophosphate, necessary for …

Where does the mevalonate pathway occur?

In higher plants, the MEP pathway operates in plastids while the mevalonate pathway operates in the cytosol. Examples of bacteria that contain the MEP pathway include Escherichia coli and pathogens such as Mycobacterium tuberculosis.

Which drug inhibits mevalonic acid pathway?

Statins are antidyslipidemic drugs that inhibit hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase in the upstream part of the mevalonate pathway and reduce cholesterol levels in blood [5].

What is mevalonic acid made from?

As its name implies, the MVA pathway utilizes mevalonate (Mev) as an important biosynthetic intermediate. This compound is derived from the condensation of two molecules of acetyl coA followed by the condensation of acetoacetyl coA with another molecule of acetyl coA to produce hydroxymethylglutaryl coA (HMG coA) (Fig.

What is end result of mevalonate pathway?

This is the only limiting rate reaction in cholesterol synthesis and is the target of statins (cholesterol-lowering drugs). …

Who introduced mevalonic acid?

discovery by Folkers. His research team also discovered mevalonic acid, which is a key substance in the production of numerous important biochemical compounds, including carotenoids, steroids, and terpenes.

How is mevalonic acid made?

Biosynthesis. Triterpenes originate from squalene via mevalonic acid, which is formed from sequential condensation of three acetyl-coenzyme A units and subsequent reduction with NADPH to generate (3S)-3-hydroxy-3-methylglutaryl-coenzyme A.